• Corpus ID: 21805259

[Synthesis and pharmacology of N-stereoisomers of quaternary tropane compounds].

@article{Ndor1987SynthesisAP,
  title={[Synthesis and pharmacology of N-stereoisomers of quaternary tropane compounds].},
  author={K. N{\'a}dor and P{\'a}l Scheiber and Egon K{\'a}rp{\'a}ti and Kurt Gr{\"o}ber},
  journal={Arzneimittel-Forschung},
  year={1987},
  volume={37 12},
  pages={
          1324-7
        }
}

• K. Nádor, P. Scheiber, +1 author K. Gröber
• Published 1 December 1987
• Chemistry
• Arzneimittel-Forschung

The synthesis of (8r)-8-(4-biphenylmethyl)-atropinium bromide (3) as N-isomeric form of xenytropium bromide, (8s)-8-(4-biphenylmethyl)-atropinium bromide (2), is reported. It was revealed, that the equatorial alkylation predominates in quaternization of tertiary tropane compounds. Furthermore, the preparation of other N-isomeric pairs of quaternary tropane derivatives in pure form is described. Xenytropium bromide is more active--16 times on the parasympathic endplate and 8 times on the ganglion--than its N-isomer.