[Synthesis and pharmacological activities of the 1-substituted 4-methoxycarbonyl fentanyl derivatives].

@article{Yi1992SynthesisAP,
  title={[Synthesis and pharmacological activities of the 1-substituted 4-methoxycarbonyl fentanyl derivatives].},
  author={Ming-lin Yi and Gengfeng Zhu and Jian Gang Li and Julie S. Chen},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={1992},
  volume={27 10},
  pages={734-7}
}
Five derivatives of 4-methoxycarbonyl fentanyl were synthesized, four of them carry in the molecules some radicals that may alkylate opiate receptors. Their analgesic activities were measured and the irreversible inhibitory effects of all compounds on the electrically elicited contraction of MVD were investigated. The analgesic test showed that the… CONTINUE READING