Corpus ID: 8061154

[Synergistic effect of toremifene and cisplatin on human lung cancer cell line A549].

@article{Zhang2002SynergisticEO,
  title={[Synergistic effect of toremifene and cisplatin on human lung cancer cell line A549].},
  author={X. Zhang and Q. Li and Yiping Han and Z. Liu},
  journal={Zhonghua zhong liu za zhi [Chinese journal of oncology]},
  year={2002},
  volume={24 6},
  pages={
          537-9
        }
}
  • X. Zhang, Q. Li, +1 author Z. Liu
  • Published 2002
  • Biology, Medicine
  • Zhonghua zhong liu za zhi [Chinese journal of oncology]
OBJECTIVE To study the toxic effect of toremifene (TOR) and its synergistic effect with cisplatin (DDP) on human lung adenocarcinoma cell line A549. METHODS The cytotoxic effects of these agents on human lung cancer cell line A549 were monitored by a tetrazolium-based colorimetric assay (MTT assay). The cell cycle and DNA content were detected by flow cytometer technic. p21 expression level was monitored by Western blot. RESULTS Toremifene inhibited the growth of A549 cell, with > or = 5… Expand
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