• Medicine
  • Published in Cirugia y cirujanos 2008

[Synergism of caffeine on antinociceptive effects of metamizole].

  title={[Synergism of caffeine on antinociceptive effects of metamizole].},
  author={Mar{\'i}a Irene D{\'i}az-Reval and Renato Galv{\'a}n-Orozco and Francisco Javier L{\'o}pez-Mu{\~n}oz and Norma Carrillo-Mungu{\'i}a},
  journal={Cirugia y cirujanos},
  volume={76 3},
BACKGROUND Combinations of analgesic drugs have been used as an option for treating pain because some types of pain are difficult to relieve with conventional analgesics. This group of drugs has been combined with analgesics or drugs without analgesic effect and is called adjuvant. One such drug is caffeine. METHODS We undertook the present study to analyze if caffeine is able to potentiate the antinociceptive effect of metamizole in the formalin model. RESULTS Metamizole produced a dose… CONTINUE READING

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