[Successful management of orthopedic operations requiring general anesthesia in a PNH patient after introduction of eculizumab].


Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder that presents with hemolytic anemia, thrombosis, and bone marrow failure. Stressors such as infection and pregnancy have been known to exacerbate hemolysis in PNH patients. Surgery can also trigger prominent complement activation and is an important risk factor for… (More)
DOI: 10.11406/rinketsu.56.423