[Study on the preparation and bio-distribution of silybin lipid nanospheres].

@article{Xu2005StudyOT,
  title={[Study on the preparation and bio-distribution of silybin lipid nanospheres].},
  author={Ximing Xu and Qiang Li and Yuan Cheng Zhu and Song Shen and Zhu Shen and Jiangnan Yu},
  journal={Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica},
  year={2005},
  volume={30 24},
  pages={1912-4}
}
OBJECTIVE To prepare silybin lipid nanospheres (SLN) and to evaluate the properties of morphology, particle size and the silybin distribution in mice. METHOD Silybin lipid nanospheres were prepared by thin film emulsion-high pressure homogenization technique. Concentrations of silybin in mice blood, liver, spleen, lung, kidney, brain, heart, stomach after oral administration were determined by high performance liquid chromatography. RESULT Scanning electron micrograph showed that most of… CONTINUE READING