• DOI:10.3736/JCIM20030117
• Corpus ID: 23008555

[Study on Realgar inducing apoptosis in T lymphocytic cell line CEM].

@article{Zhang2003StudyOR,
  title={[Study on Realgar inducing apoptosis in T lymphocytic cell line CEM].},
  author={Chen Zhang and Shi-lin Huang and Yang Xiang and Ai-xia Guo},
  journal={Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine},
  year={2003},
  volume={1 1},
  pages={
          42-3
        }
}

• Chen Zhang, Shi-lin Huang, +1 author A. Guo
• Published 1 May 2003
• Biology, Medicine
• Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine

OBJECTIVE
To study the Realgar induced T lymphocytic leukemia cell line CEM apoptosis in vitro.

METHODS
CEM cells were incubated with Realgar. Cell proliferation inhibition was determined by MTT. Cell cycle, apoptosis, Apo2.7 and Fas were measured by cytometer.

RESULTS
Realgar inhibited the proliferation of CEM cell line. The cells treated with Realgar showed a Sub-G(0)/G(1) apoptotic peak in DNA distribution histogram, increment of Apo2.7 protein expression, and arrested cells in G(2)/M phase, but ineffectiveness on Fas expression.

CONCLUSION
The Realgar can induce CEM cell apoptosis in vitro.