[Study on RNA interference reversing the multidrug resistance of leukemia cell].


OBJECTIVE To downregulate the expression of mdr1 gene in K562/A02 cell line by RNA interference. METHODS The eukaryotic expression vectors of shRNA aiming at two mdr1 mRNA target sequences were constructed and used to transfect the drug resistance cell line K562/A02 with liposome-induced gene transfection. The mRNA of mdr1 gene was identified by Q-PCR… (More)


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