[Studies on the biotransformation and anti-ulcer effects of 2-(nicotinoylaminoethanesulfonylamino)pyridine].

  title={[Studies on the biotransformation and anti-ulcer effects of 2-(nicotinoylaminoethanesulfonylamino)pyridine].},
  author={H. Tanaka and S. Naito},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  volume={85 5},
  • H. Tanaka, S. Naito
  • Published 1985
  • Chemistry, Medicine
  • Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Investigations were made of 2-(nicotinoylaminoethanesulfonylamino)pyridine (NTP), a new compound with anti-ulcer effects, to clarify the relationship between its biotransformation and pharmacological effects. The effect of NTP was investigated by using two types of experimental gastric ulcer models in rats. The anti-ulcer effect was revealed to be an action of NTP itself. In order to study the biotransformation of NTP, a quantitative analysis method by HPLC was established. When NTP was orally… Expand