[Structure and antiviral activity of an acidic polysaccharide from an edible blue-green alga, Nostoc flagelliforme].

  title={[Structure and antiviral activity of an acidic polysaccharide from an edible blue-green alga, Nostoc flagelliforme].},
  author={K. Kanekiyo and K. Hayashi and Jung-Bum Lee and H. Takenaka and Toshimitsu Hayashi},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  volume={128 5},
Recently, the development of antiviral agents with novel mechanisms of action has been required since many types of infectious disease have become a serious problem in our society. In the present study, we isolated a novel acidic polysaccharide, nostoflan (NSF), from a terrestrial blue-green alga, Nostoc flagelliforme, and examined its structure and antiviral activity. The sugar composition and methylation analyses of NSF revealed that it is mainly composed of (-->4)- D-Glcp-(1-->, -->6,4)-D… Expand
Antiviral activity of acidic polysaccharides from Coccomyxa gloeobotrydiformi, a green alga, against an in vitro human influenza A virus infection
The acidic polysaccharide fraction from a green alga Coccomyxa gloeobotrydiformi was isolated and the antiviral action on an in vitro infection of influenza A virus was examined, suggested to exhibit the anti-influenza virus activity through preventing the interaction of virus and host cells. Expand
[Antiviral action and pathogenetic targets for seaweed sulfated polysaccharides in herpesvirus infections].
A wide range of physiological action of sulfated polysaccharides, receptor agonists of innate and adaptive immune cells, open the possibility of their use for creation of new generation pharmacological substances and agents with associated activity for the treatment of herpesvirus infections. Expand
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An overview of the literature describing the potential of cyanobacterial metabolites as an alternative source for sunscreens and moisturizers is presented. Expand
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In the emerging field of algal biotechnology, optimization of algal production, engineering challenges, and scale-up of photobioreactors are urgent demands. Emphasis is placed on reducing cultivationExpand
Effect of mixed carbon substrate on exopolysaccharide production of cyanobacterium Nostoc flagelliforme in mixotrophic cultures
The effects of organic carbon sources on cell growth and exopolysaccharide (EPS) production of dissociated Nostoc flagelliforme cells under mixotrophic batch culture were investigated, and the ratio of glucose to acetate resulted in higher growth rate and higher EPS productivity with BG-110 medium. Expand


Isolation of an antiviral polysaccharide, nostoflan, from a terrestrial cyanobacterium, Nostoc flagelliforme.
Besides anti-HSV-1 activity, nostoflan showed potent antiviral activities against HSV-2, human cytomegalovirus, and influenza A virus, but no activity against adenovirus and coxsackie virus was observed. Expand
Anti-herpes simplex virus target of an acidic polysaccharide, nostoflan, from the edible blue-green alga Nostoc flagelliforme.
The results indicated that the inhibition of virus binding to but not penetration into host cells was responsible for the antiherpetic effect induced by nostoflan. Expand
Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis.
It was revealed that Ca-SP selectively inhibited the penetration of virus into host cells, and retention of molecular conformation by chelation of calcium ion with sulfate groups was suggested to be indispensable to its antiviral effect. Expand
Antiviral activities against HSV-1, HCMV, and HIV-1 of rhamnan sulfate from Monostroma latissimum.
Data indicate that RS is a potent antiviral substance against HSV-1, HCMV, and HIV-1 and that RS and 3'-azido-3'-deoxythymidine (AZT) were synergistic in their anti-HIV-1 activities. Expand
An antivirally active sulfated polysaccharide from Sargassum horneri (TURNER) C. AGARDH.
Time-of-addition experiments suggested that this sulfated polysaccharide inhibited not only the initial stages of viral infection, such as attachment to and penetration into host cells, but also later replication stages after virus penetration. Expand
Safety evaluation of Nostoc flagelliforme (nostocales, Cyanophyceae) as a potential food.
  • H. Takenaka, Y. Yamaguchi, +8 authors T. Morinaga
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1998
Findings in the oral acute toxicity study and the 28-day oral subacute toxicity study may indicate the safety of N. flagelliforme for human consumption. Expand
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Simple sugars, oligosaccharides, polysaccharides, and their derivatives, including the methyl ethers with free or potentially free reducing groups, give an orangeyellow color w-hen treated withExpand
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