[Structure-activity relationships of the thienothiazine derivatives with their antiinflammatory, analgesic and ulcerogenic effects and their inhibitory effects on PGE2 biosynthesis].

@article{Tanaka1989StructureactivityRO,
  title={[Structure-activity relationships of the thienothiazine derivatives with their antiinflammatory, analgesic and ulcerogenic effects and their inhibitory effects on PGE2 biosynthesis].},
  author={Yushiro Tanaka and Norio Himori},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year={1989},
  volume={94 1},
  pages={61-71}
}
A new series of thienothiazine derivatives were evaluated as a means of clarifying whether the changed chemical structure would have a different effect on carrageenin edema, scalded hyperalgesia and ulcerogenicity in rats and also have a different effect on PGE2 biosynthesis in vitro. The introduction of a Cl or CF3 group, but not an OH group, into position… CONTINUE READING