• Corpus ID: 29928601

[Stress-limiting properties of a new tetrahydropyrrolopyrazine derivative].

  title={[Stress-limiting properties of a new tetrahydropyrrolopyrazine derivative].},
  author={Olga V. Filippova},
  journal={Eksperimental'naia i klinicheskaia farmakologiia},
  volume={68 1},
  • O. Filippova
  • Published 2005
  • Chemistry
  • Eksperimental'naia i klinicheskaia farmakologiia
The effect of compound PV-174, selected from a series of tetrahydropyrrolopyrazine derivatives was studied on a model of immobilization stress in rats. Pretreatment with PV-174 decreases the stress-induced involution of thymus and spleen, hypertrophy of cpinephrosis, and gastric ulceration. The drug also blocks the stress-enhanced lipid peroxidation in lungs and myocardium, while not influencing the effect of kenalog (an exogenous glucocorticoid). It is suggested that one of the possible…