[Starting mechanisms of trypsinogen activation in acute pancreatitis].

Abstract

Early events critical for the development acute pancreatitis are considered. The possible initiating mechanisms of intracellular trypsinogen activation are discussed. Essential attention is paid to the role of cathepsin B, intraacinar [Ca2+] increase and free radicals generation in the premature zimogen activation. It is demonstrated, that the trypsinogen… (More)

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