Corpus ID: 39459326

[Stability of anticoagulant derivatives of 4-hydroxycoumarin. II. Structure of the principal degradation products of phenprocoumin, Clocoumarol, warfarin and acenocoumarin].

@article{Vanhaelen1978StabilityOA,
  title={[Stability of anticoagulant derivatives of 4-hydroxycoumarin. II. Structure of the principal degradation products of phenprocoumin, Clocoumarol, warfarin and acenocoumarin].},
  author={Maurice Vanhaelen and R. Vanhaelen-fastre},
  journal={Pharmaceutica acta Helvetiae},
  year={1978},
  volume={53 8},
  pages={
          221-30
        }
}
2 Citations
A stable isotope assay for phenprocoumon and its metabolites.
TLDR
A gas chromatographic/mass spectrometric assay for quantifying phenprocoumon and its 4'', 6, 7- and 8-hydroxy metabolites in microsomal preparations is described, which has a lower limit of quantitation of 20 ng ml-1. Expand
Stereochemical aspects of the metabolism of phenprocoumon in rat liver microsomes.
TLDR
Comparison of results obtained for phenprocoumon and warfarin reveals that major regioselective and stereoselectives differences exist in the in vitro metabolism of these two similar coumarin anticoagulants. Expand