[Spermiogenesis: histone acetylation triggers male genome reprogramming].

@article{Rousseaux2009SpermiogenesisHA,
  title={[Spermiogenesis: histone acetylation triggers male genome reprogramming].},
  author={Sophie Rousseaux and Jonathan Gaucher and Julien Thevenon and C{\'e}cile Caron and A-L Vitte and Sandrine Curtet and C Derobertis and A Faure and Ronald Levy and Isabelle Esther Aknin-Seifer and C{\'e}lia Ravel and J P Siffroi and K Mc Elreavey and Herv{\'e} Lejeune and Carlos A. Goribar Jim{\'e}nez and Sylviane Hennebicq and Saadi Khochbin},
  journal={Gynecologie, obstetrique & fertilite},
  year={2009},
  volume={37 6},
  pages={519-22}
}
During their post-meiotic maturation, male germ cells undergo an extensive reorganization of their genome, during which histones become globally hyperacetylated, are then removed and progressively replaced by transition proteins and finally by protamines. The latter are known to tightly associate with DNA in the mature sperm cell. Although this is a highly conserved and fundamental biological process, which is a necessary prerequisite for the transmission of the male genome to the next… CONTINUE READING

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During their post - meiotic maturation , male germ cells undergo an extensive reorganization of their genome , during which histones become globally hyperacetylated , are then removed and progressively replaced by transition proteins and finally by protamines .
During their post - meiotic maturation , male germ cells undergo an extensive reorganization of their genome , during which histones become globally hyperacetylated , are then removed and progressively replaced by transition proteins and finally by protamines .
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