[Specific inhibitors of plasminogen activators].

  title={[Specific inhibitors of plasminogen activators].},
  author={Marek Mirowski and Ryszard Wierzbicki},
  journal={Postepy higieny i medycyny doswiadczalnej},
  volume={47 2},
The article contains a survey of the recent papers on the fibrinolytic inhibitors which regulate the process of plasminogen activation--PAI-1 and PAI-2. Both of them belong to serine protease inhibitors family and are specific for tPA as well as uPA, forming stable complexes in molar ratio 1:1 with them. PAI-1, secreted mainly by endothelial cells and… CONTINUE READING