[Somatic hypermutagenesis in immunoglobulin genes. II. Properties of somatic mutations and clonal selection].

@article{Rogozin1989SomaticHI,
  title={[Somatic hypermutagenesis in immunoglobulin genes. II. Properties of somatic mutations and clonal selection].},
  author={Igor B. Rogozin and V. V. Solov'ev},
  journal={Molekuliarnaia biologiia},
  year={1989},
  volume={23 3},
  pages={795-802}
}
Analysis of the collection of 203 somatic mutations in immunoglobulin genes was carried out. It was shown, that the high frequency of these mutations in CDRs of V-genes may be connected with the high concentration of repeats in these regions. In addition, the observed clusterization of mutations may emerge from simultaneous correction of several… CONTINUE READING