[Sites and mechanisms of action of melatonin in mammals: the MT1 and MT2 receptors].

@article{Schuster2007SitesAM,
  title={[Sites and mechanisms of action of melatonin in mammals: the MT1 and MT2 receptors].},
  author={Carole Schuster},
  journal={Journal de la Societe de biologie},
  year={2007},
  volume={201 1},
  pages={
          85-96
        }
}
The rhythmic secretion of melatonin by the pineal gland plays a key role in the synchronisation of circadian and seasonal functions with cyclic environmental variations. The biological effects of this neurohormone are relayed mainly by G-protein-coupled seven-transmembrane receptors. These receptors, known as MT1 and MT2, are present in a large number of central and peripheral structures in mammals, with considerable inter-species variations. However, only the suprachiasmatic nuclei of the… CONTINUE READING