[Single nucleotide polymorphisms in XRCC1 and clinical response to platin-based chemotherapy in advanced non-small cell lung cancer].

@article{Wang2004SingleNP,
  title={[Single nucleotide polymorphisms in XRCC1 and clinical response to platin-based chemotherapy in advanced non-small cell lung cancer].},
  author={Zhonghua Wang and Xiao-ping Miao and Wen Tan and Xiang-ru Zhang and Binghe Xu and Dong-xin Lin},
  journal={Ai zheng = Aizheng = Chinese journal of cancer},
  year={2004},
  volume={23 8},
  pages={865-8}
}
BACKGROUND & OBJECTIVE DNA repair capacity correlated with sensitivity of cancer cells towards platin-based chemotherapy. This study examined the association between genetic polymorphisms of DNA repair gene XRCC1 and response to cisplatin- or carboplatin-based chemotherapy of advanced non-small cell lung cancer (NSCLC). METHODS Totally 105 patients with advanced NSCLC were routinely treated with cisplatin- or carboplatin-based chemotherapy, and clinical response was evaluated after 2 to 3… CONTINUE READING

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