• Corpus ID: 42477339

[Significance of caffeine values in serum, saliva and urine--determination of pharmacokinetic data by non-invasive methods in psychopharmacologic studies].

@article{Walther1983SignificanceOC,
  title={[Significance of caffeine values in serum, saliva and urine--determination of pharmacokinetic data by non-invasive methods in psychopharmacologic studies].},
  author={H. Walther and Peter Banditt and E K{\"o}hler},
  journal={Pharmacopsychiatria},
  year={1983},
  volume={16 5},
  pages={
          166-70
        }
}
For psychopharmacological studies with caffeine two reliable non-invasive methods are available in order to determine pharmacokinetic parameters simultaneously with psychometric tests, without any appreciable impairment of the experimental subject. The investigation were performed in 13 healthy volunteers. Caffeine was determined in serum, saliva and urine. The caffeine level in saliva was about 70% of that in serum, corresponding to the percentage freely dissolved in serum. A good correlation… 
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