[Severe toxicity following capecitabine administration because of dihydropyrimidine deshydrogenase (DPD) deficiency].


Capecitabine is an anticancer agent, prodrug of 5 fluorouracil (5-FU) administered orally and with a narrow therapeutic index. In gastrointestinal cancer, capecitabine is indicated for the treatment of colorectal cancer and metastatic unresectable gastric cancer. The 5-FU is active by incorporation in the biosynthesis of nucleic acids. Inhibition of… (More)
DOI: 10.1016/j.gcb.2009.08.014


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