[Selective gene therapy of malignant gliomas using brain-specific promoters: its efficacy and basic investigations].

Abstract

Retroviral vector is often used for gene therapy of malignant tumors. The main characteristic of this vector is that it integrates only into the genes of dividing and proliferating cells. Glioma cells proliferate actively, while surrounding normal brain cells rarely divide. Thus, we can expect the recombinant retrovirus modified to express cytotoxic genes… (More)

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