[Safety aspects of folic acid for the general population].

@article{Eichholzer2002SafetyAO,
  title={[Safety aspects of folic acid for the general population].},
  author={Monika Eichholzer and J{\"u}rg L{\"u}thy and U K Moser and Hannes B. St{\"a}helin and F{\'e}lix Gutzwiller},
  journal={Praxis},
  year={2002},
  volume={91 1-2},
  pages={
          7-16
        }
}
Periconceptional use of folic acid reduces the risk of neural tube defects considerably. In Switzerland, implementation of these findings could be improved through fortification of a staple food with folic acid. The present paper reviews possible hazards associated with high intake of folic acid in the general population. Among the potential safety issues are interaction between folic acid and zinc, interaction between folic acid and drugs (phenytoin, methotrexate etc.) and hypersensitivity to… Expand

Topics from this paper

Folic acid: a public-health challenge
TLDR
Additional creative public-health approaches need to be developed to prevent neural tube defects and improve the folate status of the general population. Expand
Neurotoxicity of Folic Acid
The present review summarises the neurotoxicological effects of folic acid. Some studies in animals have shown that folic acid is neurotoxic and epileptogenic when applied directly to the brain. OneExpand
Safety Considerations and Potential Interactions of Vitamins: Should Vitamins Be Considered Drugs?
TLDR
It is recommended that vitamins A, E, D, folic acid, and niacin should be categorized as over-the-counter medications, especially those intended for children and other vulnerable groups. Expand
Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations
TLDR
Populations from the Nordic countries, the Netherlands, Germany and Greece may need to improve their intakes of folic acid, B12 or both to either meet the recommendations or to optimize their statuses via a food-based approach, food fortification or supplements. Expand
Conséquences d'une carence en donneurs de méthyles sur la différenciation cellulaire, la survie et la neuroplasticité : approches mécanistiques in vitro sur des lignées neuronales
Les folates (vitamine B9) et la vitamine B12 interviennent comme cofacteurs dans le metabolisme des monocarbones qui regule les reactions de transmethylation impliquees dans les mecanismesExpand