[Role of endogenous tPA in stroke].

  title={[Role of endogenous tPA in stroke].},
  author={Kazuo Umemura},
  journal={Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology},
  volume={25 4},
  • Kazuo Umemura
  • Published 2005 in
    Nihon shinkei seishin yakurigaku zasshi…
The role of endogenous tissue-type plasminogen activator (tPA) on focal cerebral ischemic injury (FII) after middle cerebral artery (MCA) occlusion was studied by using tPA gene deficient (KO) mice and wild type (WT) mice. MCA was occluded by thrombosis induced by 3 different intensities of photochemical damage of MCA. FII size in KO mice was smaller than in WT mice in mild damage whereas it was larger in severe damage. These results suggested that endogenous tPA protected FII through its… CONTINUE READING