[Role of cAMP in the mechanism of the fever reaction].

  title={[Role of cAMP in the mechanism of the fever reaction].},
  author={O. M. Efremov and Alexander V. Sorokin},
  journal={Biulleten' eksperimental'noi biologii i meditsiny},
  volume={91 4},
It has been shown that accumulation of endogenous cAMP caused by theophylline increases the body sensitivity to the minimum doses of leukocytic and bacterial pyrogens and to prostaglandin E1. The increasing effect of theophylline was abolished by administering the higher doses of the pyrogenic agents. Repeated daily administration of bacterial pyrogen in… CONTINUE READING