[Role of advanced glycation endproducts in adynamic bone disease].

@article{Yamamoto2001RoleOA,
  title={[Role of advanced glycation endproducts in adynamic bone disease].},
  author={Tadashi Yamamoto and Keiichi Ozono},
  journal={Clinical calcium},
  year={2001},
  volume={11 8},
  pages={1044-7}
}
To clarify the role of AGEs in adynamic bone disease, we investigated the effect of these substances on cultured human osteoblasts and parathyroid cells. AGEs-BSA significantly inhibited parathyroid hormone secretion in response to the low calcium concentration. In HEK-293 cells, expressing calcium-sensing receptors, the same AGE concentration caused a significant potentiation of the extracellular Ca(2+) induced-intracellular calcium concentration. AGEs significantly inhibited the synthesis of… CONTINUE READING

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