[Role of Nrf2 transcription factor in cellular response to oxidative stress].

@article{Florczyk2010RoleON,
  title={[Role of Nrf2 transcription factor in cellular response to oxidative stress].},
  author={Urszula Florczyk and Agnieszka Łoboda and Anna Stachurska and Alicja J{\'o}zkowicz and Jozef Dulak},
  journal={Postepy biochemii},
  year={2010},
  volume={56 2},
  pages={
          147-55
        }
}
Nrf2 transcription factor plays a crucial role in protection of cells against oxidative stress. Under normal conditions Nrf2 is sequestered in cytoplasm by a cytoskeletal protein, Keapl. Situation is changed under stressful conditions,when electrophiles and/or reactiveoxygen species (ROS) cause dissociation of Nrf2 from Keap1. As a consequence, Nrf2 is translocated to the nucleus, that leads to activation of cytoprotective genes involved in electrophile conjugation, excretion of xenobiotics… CONTINUE READING

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