[Role of IL-22 in the pathogenesis of skin diseases].

@article{Fujita2012RoleOI,
  title={[Role of IL-22 in the pathogenesis of skin diseases].},
  author={Hideki Fujita},
  journal={Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology},
  year={2012},
  volume={35 3},
  pages={
          168-75
        }
}
  • H. Fujita
  • Published 2012
  • Biology, Medicine
  • Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
IL-22 is an IL-10 family cytokine that acts mainly on epithelial cells. It is produced by immune cell subsets, including CD4⁺ T cells, natural killer cells, and natural killer T cells. In the skin, IL-22 mediates keratinocyte proliferation and epidermal hyperplasia, inhibits terminal differentiation of keratinocytes, and induces the production of antimicrobial proteins. Although IL-22 production was initially linked with IL-17 expression in Th17 cells, IL-22 production can also occur in an… 
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13 Citations

T‐helper 22 cells as a new player in chronic inflammatory skin disorders

The role of Th22 and its cytokine IL‐22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis is discussed.

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Low plasma IL-22 levels may be a distinct feature in new-onset SLE and correlated with Th22 cell and SLE disease activity, and interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis.

Evaluation of the cutaneous expression of IL-17, IL-22, IL-31, and their receptors in canine atopic dermatitis.

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IL-22 Down-Regulates Cx43 Expression and Decreases Gap Junctional Intercellular Communication by Activating the JNK Pathway in Psoriasis.

Decreased Plasma IL‐22 Levels and Correlations with IL‐22‐Producing T Helper Cells in Patients with New‐Onset Systemic Lupus Erythematosus

Low plasma IL‐22 levels and correlation with Th22 cells may be distinct features in new‐onset SLE, and high frequencies of plasma IL-22 autoantibodies were detected in new-onsetSLE patients, while IL‐ 22 and Th22 cell correlated with SLE disease activity.

Bedside to bench: defining the immunopathogenesis of psoriatic arthritis

Data from clinical trials of novel targeted therapies for psoriatic arthritis and other autoimmune diseases, which have produced sometimes surprising results, can inform the understanding of the immunopathogenesis of these diseases and help to identify the most relevant therapeutic targets.

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It is suggested that psoriatic patients neutrophils are at a higher risk of NETosis both in vitro and in vivo, possibly due to its antioxidant properties.

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