[Rilmenidine sympatholytic activity preserves mental and orthostatic sympathetic response and epinephrine secretion].

@article{Esler2004RilmenidineSA,
  title={[Rilmenidine sympatholytic activity preserves mental and orthostatic sympathetic response and epinephrine secretion].},
  author={Murray Esler and Alan Lux and Garry L R Jennings and Jacqui Hastings and Flora Socratous and Gavin W. Lambert},
  journal={Archives des maladies du coeur et des vaisseaux},
  year={2004},
  volume={97 7-8},
  pages={
          786-92
        }
}
BACKGROUND Heightened central sympathetic nervous outflow is common in essential hypertension, contributing to hypertension development and perhaps also to complications. Acute sympathetic nervous activation is a proven trigger for adverse cardiovascular events. Accordingly, antihypertensive drugs inhibiting sympathetic outflow represent a theoretically attractive therapeutic option. OBJECTIVES To study the sympatholytic and blood pressure lowering activity of the imidazoline binding agent… 
Cause and Consequences of Sympathetic Hyperactivity in Chronic Kidney Disease
Patients with chronic kidney disease and patients undergoing hemodialysis treatment show a sustained overactivity of the sympathetic nervous system, which originates from signals arising in the
Chronically lowering sympathetic activity protects sympathetic nerves in spleens from aging F344 rats
TLDR
A protective effect of lowering sympathetic tone on sympathetic nerve integrity, and enhanced sympathetic neurotransmission in secondary immune organs is suggested.
Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders
TLDR
A potential therapeutic role for selective IBS ligands in the treatment of depression and anxiety disorders is suggested on the basis of the literature.
NEWS & VIEWS FROM RRI
Diseases of the cardiovascular system contribute significantly to the morbidity and mortality in patients with chronic renal failure (CRF) on hemodialysis treatment. Hypertension is the basis of
Targeting sympathetic glia for treating cardiovascular diseases
TLDR
The significance of satellite glia modulation of sympathetic nerve activity (SNA) in both physiology and in diseases is discussed and a new experimental strategy for manipulating satellite glial signaling in the sympathetic ganglia using adeno-associated virus (AAV) is presented.
Aging and Sympathetic Neurotransmission in Two Strains of Rats that Differ in Longevity and Immune Profiles
...........................................................................................................24 Introduction