[Reversal of anti-apoptotic action by tetrandrine in human breast carcinoma multidrug-resistant MCF-7 cells].

@article{Wang2002ReversalOA,
  title={[Reversal of anti-apoptotic action by tetrandrine in human breast carcinoma multidrug-resistant MCF-7 cells].},
  author={Jin-hua Wang and Zu-guang Ye and Ai-xu Sun and Bao-yun Xue and Ai-hua Liang and Chun-ying Li and Lan Wang},
  journal={Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica},
  year={2002},
  volume={27 1},
  pages={46-50}
}
OBJECTIVE To study whether the anti-apoptotic action is reversed by tetrandrine in a combination with vincristine in human breast carcinoma MCF-7 multidrug-resistant cells. METHOD Chromatin condensation was observed by co-staining of fluorescent dyes Hoechst 33342 and propidium iodide; and G1 sub-peak was detected by flow cytometry. Apoptotic cells were detected with TUNEL method. Cellular free ca2+ was determined with Fluo-3 staining method. RESULT Two types of chromatin condensation were… CONTINUE READING