• Medicine
  • Published in Annales d'endocrinologie 1978

[Response to ACTH of human adrenocortical cells isolated from normal glands and from adrenocortical adenoma (author's transl)].

@article{Kolanowski1978ResponseTA,
  title={[Response to ACTH of human adrenocortical cells isolated from normal glands and from adrenocortical adenoma (author's transl)].},
  author={Jaroslaw Kolanowski and Nathalie Ort{\'e}ga and J. Crabb{\'e}},
  journal={Annales d'endocrinologie},
  year={1978},
  volume={39 6},
  pages={
          485-6
        }
}
The low sensitivity of adrenocortical adenoma to ACTH, documented in vivo, and in vitro, results from decreased cAMP generation in response to ACTH while distal steps of biosynthesis of cortisol are even more active in these tumoral cells than in normal adrenocortical cells. 

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