[Resolution of thyroxine hormone enantiomers by precolumn derivatization with a fluorescent chiral reagent using reversed-phase high performance liquid chromatography].


A highly fluorescent chiral tagging reagent, R(-)-4-(N,N-dimethylaminosulfonyl)-7-(3-isothiocy-anatopyrrolidino)-2,1,3-benzoxadiazole (R(-)-DBD-PyNCS), was employed for the enantiomer separation of thyroxine hormone, D,L-3,5,3',5'-tetraiodothyronine (T4) and L-3,5,3'-triiodothyronine (T3). The reaction of R(-)-DBD-PyNCS with the thyroxine enantiomers was… (More)


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