[Research on mechanism underlying bone damage in myeloma--review].

  • Li-li Zhou
  • Published 2007 in Zhongguo shi yan xue ye xue za zhi


Multiple myeloma (MM) is a B cell malignancy characterized by enhanced bone loss that commonly associated with diffuse osteopenia, focal lytic lesions, pathologic fractures, and bone pain. The key mechanism of bone damage in myeloma is the abnormal regulation in bone metastasis, with increased osteoclast function and decreased osteoblast activity. This… (More)