[Research on a rational basis for the origin and treatment of arrhythmia].

@article{VaughanWilliams1977ResearchOA,
  title={[Research on a rational basis for the origin and treatment of arrhythmia].},
  author={E. M. Vaughan-Williams},
  journal={Acta cardiologica},
  year={1977},
  volume={Suppl 22},
  pages={
          13-32
        }
}
Electrophysiological and pharmacological studies have revealed that the anti-arrhythmic drugs in use today possess one, or more than one, of four classes of action. 1) A direct action on the cardiac membrane, comparable to the action of local anaesthetics on nerve, which prevents the heart responding at a high frequency, by interfering with the entry of fast depolarising (sodium) current. 2) An anti-sympathetic action, achieved either by competition with adrenoceptors or by blockade of the… CONTINUE READING