[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration].

  title={[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration].},
  author={Yasuyuki Okuda and Fumio Sagami and Piero Tirone and Alberto Morisetti and Simona Bussi and Robert E. L. Masters},
  journal={The Journal of toxicological sciences},
  volume={24 Suppl 1},
Gadobenate dimeglumine formulation (E7155) was daily administered by intravenous injection at 0.3, 0.9 or 2.0 mmol/kg/day to mated NZW female rabbits (20/group) to assess the effect on embryo-fetal development. Treatment with 2.0 mmol/kg/day caused initial, notable loss of body weight and reduction in food consumption. Slightly reduced body weight gain and food intake were recorded at 0.9 mmol/kg/day. There were no obvious adverse effects in dams given E7155 at 0.3 mmol/kg/day. There was a… 
Common nature in the effects of thalidomide on embryo‐fetal development in Kbl:JW and Kbl:NZW rabbits
It is concluded that there were no essential differences in sensitivity of the fetuses to thalidomide between Kbl:JW and NZW rabbits and both of the strains are useful to evaluate the teratogenic effects of thalidmide.
Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure.
The presence of gadoteridol in the amniotic fluid after maternal injection enables confirmation that it crosses the placenta, indicating that a very small amount of gadolinium persists after delivery.
Editor’s Highlight: In Utero Exposure to Gadolinium and Adverse Neonatal Outcomes in Premature Infants
Gadolinium use during pregnancy is unlikely to be associated with adverse effects in infants during the neonatal period, and there are no adverse effects on renal function or other common outcomes including degree of prematurity.
Effects of MRI Contrast Agents on Human Embryonic Lung Fibroblasts
Viability was not impaired by administration of any CM and no apoptosis was seen after tetramethylrhodamine ethyl ester staining at 24 hours of incubation and cell morphology remained unchanged in vimentin-staining for all CM and conditioning regimens.
Comparison of gadobenate dimeglumine and gadopentetate dimeglumine: a study of MR imaging and inductively coupled plasma atomic emission spectroscopy in rat brain tumors.
Gd-BOPTA is a useful contrast agent for MR imaging in brain tumors and possibly an effective absorption agent for neutron capture therapy.
Gadolinium-Based Contrast Agent-Related Toxicities
The aim of this work is to explore potential predominant gadolinium-based contrast agent-related toxicity in two cornerstone periods of the human life cycle: fetal/neonatal and adulthood/aged, and to discuss the pharmacokinetics and pharmacodynamics of gadolinian contrast agents, with a special focus on the brain.
Placental perfusion and permeability: simultaneous assessment with dual-echo contrast-enhanced MR imaging in mice.
Placental perfusion and permeability can be measured in vivo by using high gadolinium doses and a dual-echo MR imaging sequence, as assessed in mice with magnetic resonance (MR) imaging.
[Contrast media - Guidelines for practical use].
In MRI examinations, only macrocyclic contrast agents should be used for enhanced MRI exams, and there has to be a careful risk-benefit analysis with enhanced studies in pregnancy, during lactation and in the pediatric population.


A Note on the Staining of the Skeleton of Cleared Specimens with Alizarin Red S
A selective, progressive method for staining the skeleton in cleared specimens, developed with rat material, depends on obtaining the proper degree of clearing before staining.
A test for differences between treatment means when several dose levels are compared with a zero dose control.
SUMMARY Information on the biological activity of a substance is often obtained from experiments in which the treatments comprise a series of doses of the substance and a zero dose control. The aim
A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment.
Increasing doses of the substaLnce are given to groups of animals; a group of control animals receiving a zero dose are also included in the experiment.
The comparison of several dose levels with a zero dose control.
The comparison of dose treatment means with a control mean to determine the lowest dose level at which there is evidence for a difference from control was discussed recently (Williams [1971]). A test
Exact Inference for Contingency Tables with Ordered Categories
Abstract This article proposes an efficient numerical algorithm for small-sample exact inferences in contingency tables having ordinal classifications. The inferences, which apply conditional on the
Properties of Sufficiency and Statistical Tests
1—In a previous paper*, dealing with the importance of properties of sufficiency in the statistical theory of small samples, attention was mainly confined to the theory of estimation. In the present