[Reproduction study of Guanabenz, a new antihypertensive agent (3) - perinatal and postnatal test in rats].

Abstract

Guanabenz (WY-8678) was given to rats to examine its effects on dams and offspring in terms of influence on postnatal development emotion, learning and reproductive ability. The drug was administered orally to rats at 15, 8, 5, 2 and 1 mg/kg/day from the 17th day of gestation to the 21st post-partum day. The vehicle used was 5%-Arabic Gum at dose level of 5… (More)

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