[Relaxin-3 and relaxin family peptide receptors--from structure to functions of a newly discovered mammalian brain system].

@article{Kania2014Relaxin3AR,
  title={[Relaxin-3 and relaxin family peptide receptors--from structure to functions of a newly discovered mammalian brain system].},
  author={Alan Kania and Marian Henryk Lewandowski and Anna Blasiak},
  journal={Postepy higieny i medycyny doswiadczalnej},
  year={2014},
  volume={68},
  pages={
          851-64
        }
}
Relaxin-3, a member of the relaxin peptide family, was discovered in 2001 as a homologue of relaxin--a well-known reproductive hormone. However, it is the brain which turned out to be a major expression site of this newly discovered peptide. Both its molecular structure and expression pattern were shown to be very conserved among vertebrates. Extensive research carried out since the discovery of relaxin-3 contributed to the significant progress in our knowledge regarding this neuropeptide. The… 
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Relaxin-3 systems in the brain—The first 10 years
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TLDR
Overall, Relaxin-3 adopts an insulin-like fold, but the structure differs crucially from the crystal structure of human relaxin-2 near the B-chain terminus, allowing TrpB27 to interact with the hydrophobic core and partly blocks the conserved RXXXRXXI motif identified as a determinant for the interaction with the relaxin receptor LGR7.
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TLDR
The identification of relaxin-3 as the ligand for GPCR135 provides the framework for the discovery of a new brainstem/hypothalamus circuitry.
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There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male reproduction, as a neuropeptide in the central nervous system, as a
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TLDR
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TLDR
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TLDR
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TLDR
New anatomical findings support the proposition that the RLN3 system is similarly involved in the integration and modulation of behavioral activation and arousal and responses to stress in nonhuman primates and humans.
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