[Relationship between plasma concentrations of valproic acid and hepatotoxicity in patients receiving high doses].

@article{Ghozzi2011RelationshipBP,
  title={[Relationship between plasma concentrations of valproic acid and hepatotoxicity in patients receiving high doses].},
  author={Hanen Ghozzi and Alejandro Hakim and Zouhair Sahnoun and Lobna Ben Mahmoud and Rim Atheymen and Sonia Hammami and Khaled N Zeghal},
  journal={Revue neurologique},
  year={2011},
  volume={167 8-9},
  pages={600-6}
}
INTRODUCTION Valproic acid (VPA) is an anticonvulsivant drug widely prescribed in the treatment of many forms of generalized epilepsy. In literature, the incidence of liver damage induced by AVP is 0.01%. It is potentialized by the combination therapy (phenobarbital, carbamazepine). Severe hepatotoxicity is rare and appears to be independent of dose and to cause a high mortality. METHODS The aim of our study was to evaluate the relationship between plasma concentrations of AVP and the… CONTINUE READING

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