[Relationship between isometric and isotonic contractile responses of the mammalian myocardium].

@article{Bogdanov1983RelationshipBI,
  title={[Relationship between isometric and isotonic contractile responses of the mammalian myocardium].},
  author={K Iu Bogdanov and Sergey I. Zakharov and L. V. Rozenshtraukh},
  journal={Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova},
  year={1983},
  volume={69 1},
  pages={114-21}
}
Effects of 6 and 12 mM of caffeine, 10(-5) M of verapamil, variation in stimulation frequency between 0.1 and 0.7 Hz, cooling to 15 degrees C after elevation of perfusate Ca2+ to 15 mM on isometric (IM) and isotonic (IT) contractions of guinea pig papillary muscles were studied. The first and the last interventions mentioned above were found to slow down relaxation phase and increase the IT/IM response amplitude ratio by 50-70%. Under the action of both interventions the maximum of IT response… CONTINUE READING