[Relationship between BH3 mimetic S1 and expression of BCL-2 family members in acute myeloid leukemia].

Abstract

OBJECTIVE This study was to investigate the molecular biomarkers of apoptosis induced by BH3 mimetic S1 in human primary AML cells. METHODS Mononuclear cells were isolated from 27 newly diagnosed AML samples. Apoptosis was analyzed by flow cytometry. IC(50) value of S1 on these samples was determined by XTT assay. The expression level of BCL-2 family… (More)
DOI: 10.7534/j.issn.1009-2137.2015.01.008

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