[Rejection of non-immunogenic tumor cells transfected with costimulatory molecule B7 after treatment with IFN-gamma in vitro].

OBJECTIVE To explore immuno-gene-therapy of non-immunogenic tumor. METHODS Non-immurogenic tumor cells B16 were transfected with B7-1 gene. The B7-1 gene transfected B16 cells (B7+ B16) were treated with recombinant murine interferon-gamma (rmIFN-gamma) in vitro, and then inoculated to C57BL/6 mice. RESULTS While B7+ B16 cells grew progressively in… (More)