[Regulation of sphingosine kinase 1 in the TNF-α-induced expression of MUC5AC in airway epithelial cells].


OBJECTIVE To explore the effects of sphingosine kinase 1 (SphK1) on mucin (MUC)5AC overexpression under the induction of tumor necrosis factor-α (TNF-α). METHODS The HBE16 airway epithelial cells were cultured, pretreated with SphK1-specific inhibitor DMS or transfected with SphK1 siRNA. Then each group was stimulated by a certain concentration of TNF… (More)


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