[Regulation of caspase activity in apoptosis].

  title={[Regulation of caspase activity in apoptosis].},
  author={Erikki Martynova},
  journal={Bioorganicheskaia khimiia},
  volume={29 5},
Intracellular cysteine aspartate-specific proteases (caspases) play both signaling and effector roles in realizing the program of cell death. Caspases function as proteolytic cascades unique for each cell type and signal triggering apoptosis. All parts of the proteolytic cascades are duplicated and controlled by feedback signals. Amplification cycles between pairs of caspases (the third and the sixth, the ninth and the third, the twelfth and the sixth, and others) help multiply the initial… CONTINUE READING