Corpus ID: 12524220

[Reaction between 2-nitrobenzoylaminomalonate and acrylic aldehyde for the synthesis of compounds with the pyrrolo/2,1-ch h 1,4/benzodiazepine structure].

@article{Martino1976ReactionB2,
  title={[Reaction between 2-nitrobenzoylaminomalonate and acrylic aldehyde for the synthesis of compounds with the pyrrolo/2,1-ch h 1,4/benzodiazepine structure].},
  author={G. De Martino and S. Massa and R. Giuliano},
  journal={Il Farmaco; edizione scientifica},
  year={1976},
  volume={31 11},
  pages={
          785-90
        }
}
  • G. De Martino, S. Massa, R. Giuliano
  • Published 1976
  • Chemistry, Medicine
  • Il Farmaco; edizione scientifica
  • The synthesis of 5,11-dioxo-1,2,3,10,11,11a-hexahydro-5H-pyrrolo (2,1-c) (1,4)benzodiazepine and 2-bromo-5,11-dioxo-1,10,11,11a-tetrahydro-5H-pyrrolo (2,1-c) (1,4)benzodiazepin-11a-ethylcarboxylate, structurally related to anthramycin and tomaymycin, was achieved by forming in situ the pyrrolidine nucleus instead of using proline or its derivatives. The most important intermediate was 1-(2-nitrobenzoyl)-delta4-pyrrolin-2,2-dicarboxylate which was then easily transformed into the above-mentioned… CONTINUE READING