[Randomized multicenter trial of sequential methotrexate and 5-fluorouracil versus 5-fluorouracil alone in advanced gastric cancer].

@article{Sasaki1989RandomizedMT,
  title={[Randomized multicenter trial of sequential methotrexate and 5-fluorouracil versus 5-fluorouracil alone in advanced gastric cancer].},
  author={Tsuneo Sasaki and Keiichiro Ota and J Ibayashi and Yuh Sakata and Takahisa Matsuoka and Masako Ishikawa and Akira Wakui and Kyouji Ogoshi and Shugo Akazawa and Yasutaka Sakai},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  year={1989},
  volume={16 8 Pt 1},
  pages={2545-55}
}
In a recent phase II trial we have shown a favorable response rate for sequential methotrexate-5-fluorouracil (MF) in advanced gastric and colorectal cancer. We determined the therapeutic effect of sequential MF in patients with advanced gastric cancer by comparing it to 5-fluorouracil alone (F) in a randomized multicenter trial. Since February 1987 to July 1988, 133 patients with advanced gastric cancer have been prospectively randomized to receive either MF (methotrexate 100 mg/m2 i.v. push… CONTINUE READING