[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction.

  title={[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction.},
  author={Vahid Serpooshan and Senthilkumar Sivanesan and Xiaoran Huang and M. Mahmoudi and A. Malkovskiy and M. Zhao and M. Inayathullah and D. Wagh and Xuexiang J Zhang and Scott Metzler and D. Bernstein and J. Wu and P. Ruiz-Lozano and J. Rajadas},
  • Vahid Serpooshan, Senthilkumar Sivanesan, +11 authors J. Rajadas
  • Published 2015
  • Materials Science, Medicine
  • Biomaterials
  • Nanoparticle-mediated sustained delivery of therapeutics is one of the highly effective and increasingly utilized applications of nanomedicine. Here, we report the development and application of a drug delivery system consisting of polyethylene glycol (PEG)-conjugated liposomal nanoparticles as an efficient in vivo delivery approach for [Pyr1]-apelin-13 polypeptide. Apelin is an adipokine that regulates a variety of biological functions including cardiac hypertrophy and hypertrophy-induced… CONTINUE READING
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