• DOI:10.1016/j.biomaterials.2014.08.045
Corpus ID: 10241903

[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction.

@article{Serpooshan2015Pyr1Apelin13DV,
  title={[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction.},
  author={Vahid Serpooshan and Senthilkumar Sivanesan and Xiaoran Huang and M. Mahmoudi and A. Malkovskiy and M. Zhao and M. Inayathullah and D. Wagh and Xuexiang J Zhang and Scott Metzler and D. Bernstein and J. Wu and P. Ruiz-Lozano and J. Rajadas},
  journal={Biomaterials},
  year={2015},
  volume={37},
  pages={
          289-98
        }
}

Vahid Serpooshan, Senthilkumar Sivanesan, +11 authors J. Rajadas

Published 2015

Materials Science, Medicine

Biomaterials

Nanoparticle-mediated sustained delivery of therapeutics is one of the highly effective and increasingly utilized applications of nanomedicine. Here, we report the development and application of a drug delivery system consisting of polyethylene glycol (PEG)-conjugated liposomal nanoparticles as an efficient in vivo delivery approach for [Pyr1]-apelin-13 polypeptide. Apelin is an adipokine that regulates a variety of biological functions including cardiac hypertrophy and hypertrophy-induced… CONTINUE READING

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