[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction.

@article{Serpooshan2015Pyr1Apelin13DV,
  title={[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction.},
  author={Vahid Serpooshan and Senthilkumar Sivanesan and Xiaoran Huang and M. Mahmoudi and A. Malkovskiy and M. Zhao and M. Inayathullah and D. Wagh and Xuexiang J Zhang and Scott Metzler and D. Bernstein and J. Wu and P. Ruiz-Lozano and J. Rajadas},
  journal={Biomaterials},
  year={2015},
  volume={37},
  pages={
          289-98
        }
}
  • Vahid Serpooshan, Senthilkumar Sivanesan, +11 authors J. Rajadas
  • Published 2015
  • Materials Science, Medicine
  • Biomaterials
  • Nanoparticle-mediated sustained delivery of therapeutics is one of the highly effective and increasingly utilized applications of nanomedicine. Here, we report the development and application of a drug delivery system consisting of polyethylene glycol (PEG)-conjugated liposomal nanoparticles as an efficient in vivo delivery approach for [Pyr1]-apelin-13 polypeptide. Apelin is an adipokine that regulates a variety of biological functions including cardiac hypertrophy and hypertrophy-induced… CONTINUE READING
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    References

    SHOWING 1-10 OF 86 REFERENCES
    A novel self-assembly albumin nanocarrier for reducing doxorubicin-mediated cardiotoxicity.
    • 40
    Surface modification of liposomes for selective cell targeting in cardiovascular drug delivery.
    • 118
    Liposomal drug delivery systems: from concept to clinical applications.
    • 2,430
    • PDF
    Targeted liposomal drug delivery in cancer.
    • 170
    Targeted drug delivery utilizing protein-like molecular architecture.
    • 50
    Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery.
    • 150
    • PDF
    Targeting liposomes with protein drugs to the blood-brain barrier in vitro.
    • 98
    Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes.
    • 229