[Psychiatric and neuropsychological signs and symptoms in patients with fabry disease: literature review].

@article{Mller2005PsychiatricAN,
  title={[Psychiatric and neuropsychological signs and symptoms in patients with fabry disease: literature review].},
  author={Matthias J. M{\"u}ller and K-M M{\"u}ller and Angela Smaranda Dascalescu and Catharina Whybra and Ken I Baron and Armin Scheurich and Karl Mann and Marcus R. Beck and Lutz Schmidt and Andreas Fellgiebel},
  journal={Fortschritte der Neurologie-Psychiatrie},
  year={2005},
  volume={73 11},
  pages={
          687-93
        }
}
Fabry Disease (FD) is an X-linked lysosomal storage disorder (prevalence about 1 : 100 000) caused by a genetic defect associated with a lack of alpha-galactosidase A (alpha-GAL) enzyme activity. As a consequence, neutral glycosphingolipides can not be cleaved and metabolized, and accumulate in lysosomes of several tissues, particularly in vascular endothelium and smooth muscle cells. The most prominent symptoms comprise pain attacks and acroparesthesia, angiokeratoma, corneal opacity, renal… CONTINUE READING