[Protective effect of tripchlorolide on dopaminergic neurons in partially lesioned rat model of Parkinson's disease].

@article{Cheng2002ProtectiveEO,
  title={[Protective effect of tripchlorolide on dopaminergic neurons in partially lesioned rat model of Parkinson's disease].},
  author={Xiao-xin Cheng and Feng-qiao Li and Min Huang and Xiao-min Wang and Ji-sheng Han},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={2002},
  volume={37 5},
  pages={
          339-42
        }
}
AIM To study whether the immunosuppressant tripchlorolide (T4) exerts neuroprotective effect on dopaminergic neurons. METHODS A rat model of Parkinson's disease (PD) was set up by transection of the medial forebrain bundle (MFB) with a wire knife. The rotational behavior, HPLC-ECD, tyrosine hydroxylase (TH) immunocytochemistry, ELISA methods were used to evaluate the influence on the dopaminergic neurons following T4 treatment. RESULTS T4 treatment was shown to effectively attenuate the… CONTINUE READING