[Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein].

@article{Timofeev2001ProtectiveAO,
  title={[Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein].},
  author={Andrei Timofeev and Iu Iu Kondrat'eva and Galina G. Karganova and J T Stephenson},
  journal={Voprosy virusologii},
  year={2001},
  volume={46 1},
  pages={22-4}
}
Three intramuscular injections (50 micrograms each) with bacterial plasmid pMV45 carrying nonstructural gene of NS1 protein of tick-borne encephalitis (TBE) virus protected 88% Balb/c mice from lethal challenge with the virus. Antibodies to NS1 nonstructural protein were detected in the sera of vaccinated mice after the challenge. Absence of antibodies to E structural protein indicated absence of manifest infectious process in mice vaccinated with plasmid and challenged with a lethal dose of… CONTINUE READING

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