[Propofol infusion syndrome].

  title={[Propofol infusion syndrome].},
  author={Johann Motsch and Jens Roggenbach},
  journal={Der Anaesthesist},
  volume={53 10},
  pages={1009-22; quiz 1023-4}
Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate acidosis and muscular necrosis. It has been postulated that propofol might act as a trigger substrate in the presence of priming factors. Severe… CONTINUE READING
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